Genetic or immune defects may impair ability to fight Covid-19

Exclusive: significant proportion of severely ill people have inborn errors, study finds

A significant proportion of patients who develop life-threatening forms of Covid-19 have genetic or immunological defects that impair their ability to fight the virus, research has found.

In papers published in the journal Science, the Covid Human Genetic Effort international consortium describes two glitches in severely ill Covid-19 patients that prevent them from making a frontline immune molecule called type 1 interferon.

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